These cuts to physics research will be a disaster for UK scientists – and for our standing in the world | Jon Butterworth

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Although many scientists today assume that Sanger was the first to figure out how to sequence DNA, that’s not the case. As with RNA, Sanger was edged out by a Cornell biochemist. This time it was Ray Wu, who, in 1970, published a method to “read” specific sections of two bacterial virus genomes, called λ and bacteriophage 186. Wu’s method was only capable of sequencing “cohesive ends,” short single-stranded sections of these particular phage genomes, and so wasn’t considered a “general” solution to the DNA sequencing problem. In 1974, Wu’s lab refined this technique into the first general sequencing method, but it proved extremely labor-intensive and failed to catch on.

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Well, if we even had that concept.

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